Search results for "Neuroblastoma stage"

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Influence of Neuroblastoma Stage on Serum-Based Detection of MYCN Amplification

2009

BACKGROUND: MYCN oncogene amplification has been defined as the most important prognostic factor for neuroblastoma (NB), the most common solid extracranial neoplasm in children. High copy numbers are strongly associated with rapid tumor progression and poor outcome, independently of tumor stage or patient age, and this has become an important factor in treatment stratification. PROCEDURE: By real-time quantitative PCR analysis, we evaluated the clinical relevance of circulating MYCN DNA of 267 patients with locoregional or metastatic NB in children less than 18 months of age. RESULTS: For patients in this age group with INSS stage 4 or 4S NB and stage 3 patients, serum-based determination o…

Neuroblastoma stageGenes mycArticleNeuroblastomaPatient ageNeuroblastomaGene duplicationmedicineNeoplasmHumansChildneoplasmsRetrospective StudiesNeoplasm Stagingbusiness.industryGene AmplificationChild; DNA Neoplasm/blood; Gene Amplification; Genes myc; Humans; Neoplasm Staging; Neuroblastoma/genetics; Neuroblastoma/pathology; Retrospective StudiesRetrospective cohort studyHematologyDNA Neoplasmmedicine.diseaseOncologyTumor progressionPediatrics Perinatology and Child HealthMycn amplificationCancer researchbusiness
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L'ESPLORAZIONE DEI LINFONODI REGIONALI NEL NEUROBLASTOMA LOCALIZZATO: Compliance alle Direttive Chirurgiche nello Studio Nazionale NB 85

1993

Accurate staging of patients with Neuroblastoma is essential for prognosis and for determining the most appropriate treatment. The neoplastic involvement of regional lymph-nodes (l.n.) is an important prognostic feature; the surgical exploration of these L.n. is mandatory for localized neuroblastoma (NBL) (stage I and II) in wich surgery represent the main treatment. The Authors have carried out a retrospective analysis of the cases registered in Italy between 1985 and 1989

Settore MED/38 - Pediatria Generale E SpecialisticaSettore MED/20 - Chirurgia Pediatrica E InfantilePediatric tumours Neuroblastoma stage I and II treatment surgery surgical exploration of regional lymphnodes.
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